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EC number: 218-485-4
CAS number: 2162-73-4
Table 1: Clinical signs and mortality
Dose (mg/kg bw)
Table 2: Body weight
Dose (mg/kg bw)
Body weight (percent controls at week 12
Table 3: Histopathology
(accumulation of mucoid material in the bronchioles)
- mild to moderate
- moderate to severe
- less severe
study was conducted to provide information on the possible health
hazards likely to arise from repeated treatment with the test article
m-tolylidene diisocyanate (Gordon, 1978). The test material was
administered once daily via oral gavage, 5 days a week, for 13 weeks.
The test material was solved in corn oil and administered to
six groups, each of ten male and ten female Fischer344 rats, at dietary
concentrations of 15, 30, 60, 120 and 240 mg/kg/day. A further group of
ten males and ten females was exposed to vehicle only to serve as a
control. Clinical signs and bodyweight
development were monitored during the study. All animals were subjected
to gross necropsy examination and a comprehensive histopathological
evaluation of organs and tissues was performed.
were mortalities and clinically observable signs of toxicity in the test
animals the study period. Of the Males treated with 60 mg/kg bw 1 animal
died. Additionally 2 males died in the 120 mg/kg bw group and 1 died in
the 240 mg/kg bw group. One intercurrent death was noted in females
treated at 240 mg/kg bw, which was judged to be related to treatment. 1
of 10 males (60 and 120 mg/kg bw) and 3 males (240 mg/kg bw) showed
respiratory noises. A slight decrease in body weights of males treated
with 60 mg/kg bw and above was evident (down to 89.7 % of the controls
in the 240 mg/kg bw dose group) and in females treated with 120 mg/kg bw
and above . Toxicological significant effects (respiratory noises) noted
were detected in male animals treated with 60, 120 and 240 mg/kg bw.
Histopathological findings were detected in males treated at 60 mg/kg bw
and above and in females treated at 120 mg/kg bw and above a
dose-related appearance of accumulated mucoid material in the pulmonary
bronchioles. Thus, in this rat subchronic repeat dose toxicity study,
the No-Observable-Adverse-Effect Level (NOAEL) of the test article
m-tolylidene diisocyanate for males is 30 mg/kg/day and for females 60
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