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EC number: 218-485-4
CAS number: 2162-73-4
No hazard to the environment has been
determined for the registered substance in any acute or chronic
ecotoxicological study available to date. Due to the fast hydrolysis
(DT50 = 37s, Neuland 2020) and the poor water solubility (0.005414 mg/L,
WSKOW 2012), which could not be determined experimentally thereby, the
preparation of test solutions with TRIDI was very difficult. As
recommended in the OECD Guidance Document No. 23 on aqueous phase
aquatic toxicity testing of difficult test chemicals (second edition,
February 2019) solubility pre-experiments including analytical dose
verification were performed before initiation of any aquatic toxicity
testing to determine the maximum dissolved concentration that can be
achieved in the specific test solution under test conditions. In the
long-term studies, the maintenance and reproducibility of test medium
concentrations could only be achieved by the use of the solvent DMF,
which limited the concentration of the test solutions. It can therefore
be concluded that no effects have been determined up to the "water
solubility" of the test substance or rather the highest possible
concentration of the test substance in water. Hence, it is expected that
the test substance poses no hazard to the environment based on the
all available data on short- and long-term toxicity to aquatic organisms
and taking into account the poor water solubility of the registered
substance (0.005141 mg/L at 25°C calculated by KOWWIN), no acute or
chronic hazard was determined for the aquatic environment up to and
clearly above the limit of solubility or relevant limit concentrations,
whichever is the lowest. Furthermore rapid degradation from the
environment is proven by the fast hydrolysis ((DT50= 37s, Neuland 2020).
Hence, no acute or chronic hazard was determined for the aquatic
environment and the substance does not need to be classified according
to Regulation (EC) No 1272/2008.
to the rapid hydrolysis of the registered substance and due to the
design and duration of the aquatic studies conducted, the determination
of the toxicity of the degradation products was automatically included.
Confirmation of this is provided by the analytical measurements for dose
verification accompanying the long-term studies, for which the sum of
TRIDI and the main hydrolysis product TRIDA was determined. Since
neither an acute nor a chronic effect was determined in the available
aquatic studies for all trophic levels up to the solubility limit or
relevant limit concentrations, an acute or chronic toxicity of the
degradation products in the relevant concentrations can also be
excluded. Furthermore, the results of the available bioaccumulation
study with the main hydrolysis product TRIDA (Gourlay, 2021) confirm,
that there is no potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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