Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-485-4 | CAS number: 2162-73-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 7.42 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 7.42 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.742 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 0.742 µg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 100 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 400.2 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 40.02 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 79.8 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 0.24 mg/kg food
- Assessment factor:
- 3 000
Additional information
No hazard to the environment has been determined for the registered substance in any acute or chronic ecotoxicological study available to date. Due to the fast hydrolysis (DT50 = 37s, Neuland 2020) and the poor water solubility (0.005414 mg/L, WSKOW 2012), which could not be determined experimentally thereby, the preparation of test solutions with TRIDI was very difficult. As recommended in the OECD Guidance Document No. 23 on aqueous phase aquatic toxicity testing of difficult test chemicals (second edition, February 2019) solubility pre-experiments including analytical dose verification were performed before initiation of any aquatic toxicity testing to determine the maximum dissolved concentration that can be achieved in the specific test solution under test conditions. In the long-term studies, the maintenance and reproducibility of test medium concentrations could only be achieved by the use of the solvent DMF, which limited the concentration of the test solutions. It can therefore be concluded that no effects have been determined up to the "water solubility" of the test substance or rather the highest possible concentration of the test substance in water. Hence, it is expected that the test substance poses no hazard to the environment based on the available data.
Conclusion on classification
Considering all available data on short- and long-term toxicity to aquatic organisms and taking into account the poor water solubility of the registered substance (0.005141 mg/L at 25°C calculated by KOWWIN), no acute or chronic hazard was determined for the aquatic environment up to and clearly above the limit of solubility or relevant limit concentrations, whichever is the lowest. Furthermore rapid degradation from the environment is proven by the fast hydrolysis ((DT50= 37s, Neuland 2020). Hence, no acute or chronic hazard was determined for the aquatic environment and the substance does not need to be classified according to Regulation (EC) No 1272/2008.
Due to the rapid hydrolysis of the registered substance and due to the design and duration of the aquatic studies conducted, the determination of the toxicity of the degradation products was automatically included. Confirmation of this is provided by the analytical measurements for dose verification accompanying the long-term studies, for which the sum of TRIDI and the main hydrolysis product TRIDA was determined. Since neither an acute nor a chronic effect was determined in the available aquatic studies for all trophic levels up to the solubility limit or relevant limit concentrations, an acute or chronic toxicity of the degradation products in the relevant concentrations can also be excluded. Furthermore, the results of the available bioaccumulation study with the main hydrolysis product TRIDA (Gourlay, 2021) confirm, that there is no potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
