Registration Dossier
Registration Dossier
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EC number: 701-402-5 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov 1992 to May 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Study, no guideline available
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- EC Number:
- 243-528-9
- EC Name:
- Dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- Cas Number:
- 20120-33-6
- Molecular formula:
- C6H14NO5P
- IUPAC Name:
- dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- Reference substance name:
- Dimethyl (3-amino-3-oxopropyl)phosphonate
- EC Number:
- 219-765-9
- EC Name:
- Dimethyl (3-amino-3-oxopropyl)phosphonate
- Cas Number:
- 2526-69-4
- Molecular formula:
- C5H12NO4P
- IUPAC Name:
- dimethyl (3-amino-3-oxopropyl)phosphonate
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Test animals
- Species:
- pig
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The study was performed to investigate the potential of Pyrovatex CP neu to be absorbed through pig ear skin. 339 (0.1 of the test material were applied to the skin. After 0, 0.5, 1.0, 2.0, 4.0, 6.0, 8.0 and 24 hours a volume of 0.5 ml was obtained, which was analysed with a gaschromatographical method (HRGC)/ECD-Detection. The test material could not be detected in the receptor chamber at the time intervals investigated (0-24 hours). A penetration could not be observed. The results are referred to the ECD-active compounds of Pyrovatex CP neu.
In conclusion, it can be stated that during the described skin penetration assay and under the experimental conditions reported, the test article did not penetrate through pig ear skin.
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