Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-940-2 | CAS number: 502-49-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- intraperitoneal injection
- Type of information:
- experimental study
- Remarks:
- publication
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- only short report
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicité pour la Souris de quelques cyclanones
- Author:
- Caujolle F, Caujolle D, Foulquier J
- Year:
- 1 962
- Bibliographic source:
- Compt. Rend. Acad. Sci. Paris 254, 2245-6.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Swiss mice were given intraperitoneally solns, of cyelopentanone (I), cyclohexanone (II), cycloheptanone (III), and cyclo-octanone (IV) in neutralized olive oil. The observation period was 30 days. Letal doses, clinical signs and body temerature were collected.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclooctanone
- EC Number:
- 207-940-2
- EC Name:
- Cyclooctanone
- Cas Number:
- 502-49-8
- Molecular formula:
- C8H14O
- IUPAC Name:
- cyclooctanone
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- weight: 20 - 22 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.74 other: g/kg
- Remarks on result:
- other: LD50: 0.74 g/kg equals 5.8 mM/kg
- Clinical signs:
- immediately after injection agitation and aggressivity , followed by coma, bradypnea, arrhythmia, loss of musclue tone and fast death
- Other findings:
- Decrease in body temperature at LD50: 3.0 °C (max. 3.7°C)
Any other information on results incl. tables
At lower doses, the animals were restless and aggressive, followed by a stage of torpor. The respiration was first accelerated, then became slower and arythmic, accompanied by a drop in body temperature. The time until seizure was determined to be 6h for cyclooctanone.
Applicant's summary and conclusion
- Conclusions:
- Based on limited reliability of the study, cyclooctanone does not require classification for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
