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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Remarks:
publication
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
only short report

Data source

Reference
Reference Type:
publication
Title:
Gradient de toxicité des cyclanones.
Author:
Caujolle D and Caujolle F
Year:
1965
Bibliographic source:
Compt. Rend. Acad. Sci. Paris 261, 1781-1783.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Rats and mice were exposed to cycloalkanones. LD50 values in mM/kg following intraperitoneal injection into mice and rats and LD50 values in mM/kg following peroral exposure in mice were obtained.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclooctanone
EC Number:
207-940-2
EC Name:
Cyclooctanone
Cas Number:
502-49-8
Molecular formula:
C8H14O
IUPAC Name:
cyclooctanone

Test animals

Species:
other: mouse and rat
Strain:
other: Swiss mice, Wistar rats
Sex:
male/female

Administration / exposure

Route of administration:
other: oral via gavage, i.p. via injection
Vehicle:
other: pure or in olive oil
Control animals:
not specified
Details on study design:
Wistar rats of both sexes (190±10g) were exposed to cyclooctanopne in neutralised olive oil. Oral application of pure or oily soultion of cyclooctanone was performed.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
10.03 other: mM/kg
Based on:
test mat.
Clinical signs:
other: dizziness, prostration, reduced muscle tone, pain sensitivity, accelerated breathing
Gross pathology:
no specific pattern but seen tubulointerstitial nephritis, degenerative lesions in liver and rarely pancreatic necrosis

Any other information on results incl. tables

Table: LD50 values for cyclooctanone

Species

Route

LD50

mouse

i.p.

5.8 mM/kg equals ca. 0.74 g/kg

mouse

oral

10.03 mM/kg  equals ca. 1.31 g/kg

rat

i.p

5.16 mM/kg  equals ca. 0.66 g/kg

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
reliability 4
Conclusions:
Based on limited reliability of the study, cyclooctanone does not require classification for acute toxicity.