Cyclooctanone

Endpoint summary

Description of key information

Two publications considered of being not assignable were available dealing with acute toxicity of cyclooctanone (Caujolle and Caujolle, 1965; Caujolle et al. 1962). Based on limited reliability of the studies, cyclooctanone does not require classification for acute toxicity.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Remarks:

publication

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Remarks:

only short report

Qualifier:

no guideline available

Principles of method if other than guideline:

Rats and mice were exposed to cycloalkanones. LD50 values in mM/kg following intraperitoneal injection into mice and rats and LD50 values in mM/kg following peroral exposure in mice were obtained.

GLP compliance:

not specified

Species:

other: mouse and rat

Strain:

other: Swiss mice, Wistar rats

Sex:

male/female

Route of administration:

other: oral via gavage, i.p. via injection

Vehicle:

other: pure or in olive oil

Control animals:

not specified

Details on study design:

Wistar rats of both sexes (190±10g) were exposed to cyclooctanopne in neutralised olive oil. Oral application of pure or oily soultion of cyclooctanone was performed.

Sex:

male/female

Dose descriptor:

LD50

Effect level:

10.03 other: mM/kg

Based on:

test mat.

Clinical signs:

other: dizziness, prostration, reduced muscle tone, pain sensitivity, accelerated breathing

Gross pathology:

no specific pattern but seen tubulointerstitial nephritis, degenerative lesions in liver and rarely pancreatic necrosis

Table: LD50 values for cyclooctanone

Species	Route	LD50
mouse	i.p.	5.8 mM/kg equals ca. 0.74 g/kg
mouse	oral	10.03 mM/kg  equals ca. 1.31 g/kg
rat	i.p	5.16 mM/kg  equals ca. 0.66 g/kg

Interpretation of results:

study cannot be used for classification

Remarks:

reliability 4

Conclusions:

Based on limited reliability of the study, cyclooctanone does not require classification for acute toxicity.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

1 310 mg/kg bw

Quality of whole database:

limited reliablity due to publication with insufficient documentation

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Caujolle and Caujolle (1965) and Caujolle et al. (1962) reported LD50 values of 0.74 g/kg in mice and 0.66 g/kg in rat following i.p. application of cyclooctanone.

Justification for classification or non-classification

Based on limited reliability of the published data on acute toxicity (insufficient documentation), cyclooctanone does not require classification for acute toxicity.