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EC number: 214-275-1
CAS number: 1119-34-2
L-argine-HCl is neither irritating or corrosive to skin nor irritating to eyes as well as to the respiratory system.
The cell viability was measured by determining the optical density (OD)
at a wavelength of 540 nm. An exposure time of 20 minutes was employed.
The mean viability of the cells exposed to the test item was 98.0% of
the mean negative control value. The OD540 values were well above the
cut-off percentage cell viability value that distinguishes irritant from
non-irritant test items of >50% for a 20-minute exposure.
The test item was considered to be non-cytotoxic and predicted to be not
irritant to skin.
The viability of cells treated with the positive reference item, 5% SDS,
was 6.9% of the negative controls and was below the cut-off value.
Hence, 5% SDS is predicted to cause pronounced skin irritation.
All quality criteria required were fulfilled.
The dermal irritant potential of L-arginine-HCl was assessed in a
GLP gudeline study according to OECD 439 (three-dimensional
reconstructed human epidermis model) by application of the product
to the test system. L-arginine-HCl did not show to be irritatting
to the skin and is not classified as irritating or corrosive to human
The eye irritant potential of L-arginine-HCl was assessed by
application of the dry product to the eyes of three rabbits in
accordance with OECD guideline 405. L-argine-HCl did not show any eye
irritancy potential in an in vitro GLP study using fertile chicken eggs
(HET-CAM test). The substance did not show any eye irritation. The
product is classified as not-irritating to human eye.
There are no data available which indicate that L-arginine-HCl is
irritant to the respiratory system.
Justification for selection of skin irritation / corrosion endpoint:
Justification for selection of eye irritation endpoint:
L-arginine-HCl does not show any irritating or corrosive properties
towards both the skin and the eyes. Thus classification is not required.
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