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EC number: 214-275-1 | CAS number: 1119-34-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The short-term toxicity of L-arginine-HCl to fish is estimated by read-across from L-arginine.
The test results for acute toxicity of L-arginine to fish were: LC50 = 2.8 g/l; LC 100 = 5.6 g/l; NOEC (mortality) = 1.8 g/l; NOEC (condition) = 1.0 g/l.
These results are converted bases upon the ratio of the molecular weight. The results applying for Arg-HCl are.
LC50 = 3.4 g/l; LC 100 = 6.8 g/l; NOEC (mortality) = 2.2 g/l; NOEC (condition) = 1.2 g/l.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 3.4 g/L
Additional information
A limit test according to OECD 203 did not show any adverse effects to fish at a test concentration of 1 g/L L-arginine. A subsequent test with L-arginine according to OECD 203 with higher test concentrations showed the following results: LC50 = 2.8 g/l; LC 100 = 5.6 g/l; NOEC (mortality) = 1.8 g/l; NOEC (condition) = 1.0 g/l.
These results are converted bases upon the ratio of the molecular weight. The results applying for Arg-HCl are.
LC50 = 3.4 g/l; LC 100 = 6.8 g/l; NOEC (mortality) = 2.2 g/l; NOEC (condition) = 1.2 g/l.
There is weight of evidence from the behaviour of L-arginine-HCl in aqueous solution as well as from QSAR modelling that read-across from L-arginine to L-arginine-HCL is justified for the endpoint short-term toxicity to fish.
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