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EC number: 214-275-1
CAS number: 1119-34-2
LD50 of L-argine-HCl was determined to be 12400 mg/kg b.w. in a scientific study with rats. L-arginine-HCl is practically non-toxic. The studies for acute dermal toxicity and toxicity via the inhalation route were waived due to the results from oral toxictiy studies.
LD50 of L-arginine-HCl was determined to be 12400 mg/kg b.w. in a
scientific study with rats. This
is in line with a study with L-arginine in which no toxicity occured up
to the maximum test dose which was just 5110 mg/kg.
result shows that the toxicity of L-arginine-HCl via the oral route is
extremely low. Inhalation is not a relevant route based upon the vapour
pressure and particle size (granulometry) of L-arginine-HCl. There is
sufficient weight of evidence for the absence of acute toxicity via the
absence of acute toxic effects even at application of increased value
doses indicates a low systemic toxicity of L-arginine-HCl.
data on acute dermal toxicity for L-arginine-HCl or L-arginine is
available. Due to its very low systemic toxicity and the fact that
L-arginine-HCl (with high water solubility and a log P value well below
0) may be too hydrophilic to cross the lipid rich environment of the
stratum corneum it is highly improbable that an acute dermal toxicity
study would result in any toxicity.
Justification for selection of acute toxicity – oral endpoint
Based on the data available no classification for acute toxicity (oral
toxicity, dermal toxicity, inhalation toxicity) is required.
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