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EC number: 214-275-1
CAS number: 1119-34-2
The experimental aquatic toxicity of L-arginine-HCl is derived by
read-across from studies with L-arginine as there is weight of evidence
from the behaviour of L-arginine-HCl in aquous soluation that
read-across from L-arginine to L-arginine-HCL is justified for aquatic
The results from studies for short-term toxicity to fish and daphniae
reveal that L-arginine-HCl does not show aquatic toxicity and does not
The test results for acute toxicity of L-arginine to fish were:
LC50 = 2.8 g/l; LC 100 = 5.6 g/l; NOEC (mortality) = 1.8 g/l; NOEC
(condition) = 1.0 g/l.
These results are converted based upon the ratio of the molecular
weight. The results applying for Arg-HCl are:
LC50 = 3.4 g/l; LC 100 = 6.8 g/l; NOEC (mortality) = 2.2 g/l; NOEC
(condition) = 1.2 g/l.
The test results for acute toxicity of
L-arginine to daphniae were:
EC50 = 1.8 g/l; EC 100 = 5.6 g/l. NOEC (mobility) was estimated to
be 1.0 g/l and NOEC (condition) was estimated to be < 1.0 g/l.
EC50 = 2.2 g/l; EC 100 = 6.8 g/l. NOEC (mobility) was estimated to
be 1.2 g/l and NOEC (condition) was estimated to be < 1.2 g/l.
The CSA did not trigger testing for long-term toxicity with fish
or aquatic invertebrates.
EC50 for algae was calculated to be ca. 26857 mg/L.
toxicity of L-arginine-HCl to microorganisms was derived to be EC 10 >
10 g/kg by read-across from L-arginine.
Considering the results from higher trophic levels as well as for
microorganisms and an expert statement (see endpoint summary in IUCLID
section 6.1.5) toxicity testing with aquatic algae was not deemed
These results do not trigger classification.
In respect of REACH Art. 14 in conjunction with REACH Annex I a CSA is
required which includes an exposure assessment if the particular
substance fulfils the criteria for any of most hazard classes or
categories set out in Annex I to regulation 1272/2008 or is assessed to
be a PBT / vPvB (for details see REACH Annex I, Section 0.6.3.). Annex
I, Section 5.0 of the REACH Regulation states that the exposure
assessment “shall cover any exposures that may relate to the hazards
identified in Sections 1 to 4”.
Thus REACH requires that the exposure assessment is closely linked to
the hazard assessment, which may identify hazards either for the
environment, or for human health, or for both. The hazard assessment
(including the classification) as well as the performance of an exposure
assessment are focused either on possible effects on the environment or
on possible effects on human health. Thus, any substance of a nature
identified as hazardous to human health (and a respective
classification) triggers an assessment of the exposure of humans, but
not of the environment. L-arginine-HCl does not fulfil the criteria
relating to environmental hazards (wording of EU-GHS, in particular Art.
3). Thus an exposure assessment within the Chemical Safety Assessment
for L-arginine-HCl is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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