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EC number: 813-937-2 | CAS number: 111512-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 260 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 260 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Corrected NOAEC = 62,671 x 6/8 x 6.7/10 = 31,492 mg/m3
Overall, the DNEL for long-term occupational exposure by inhalation is calculated by dividing the corrected NOAEC by the assessment factors (AF):
DNEL (long-term effects in workers) = 31,492 / (2.5 x 5 x 2 x 1 x 1) =1,260 mg/m3=207 ppm
- AF for dose response relationship:
- 1
- Justification:
- A factor of 1 addresses dose response.
- AF for differences in duration of exposure:
- 2
- Justification:
- A factor of 2 is considered appropriate for exposure duration as the starting point is the NOAEC from a 90-day study.
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- 2.5 was used to address the interspecies extrapolation (toxicodynamic differences)
- AF for intraspecies differences:
- 5
- Justification:
- 5 was considered appropriate to address the intraspecies extrapolation (worker sub-population).
- AF for the quality of the whole database:
- 1
- Justification:
- A factor of 1 is considered appropriate for the quality of the database.
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 69 365 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 69 365 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Corrected NOAEC = 1,294,114 x 6.7/10 = 867,056 mg/m3
Overall, the DNEL for systemic effects following acute occupational exposure by inhalation is calculated by dividing the corrected NOAEC by the assessment factors (AF):
DNEL (long-term effects in workers) =867,056 /(2.5 x 5 x 1 x 1 x 1) =69,365 mg/m³ = 11,422 ppm
- AF for dose response relationship:
- 1
- Justification:
- A factor of 1 addresses dose response.
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- 2.5 was used to address the interspecies extrapolation (toxicodynamic differences)
- AF for other interspecies differences:
- 1
- AF for intraspecies differences:
- 5
- Justification:
- 5 was considered appropriate to address the intraspecies extrapolation (worker sub-population).
- AF for the quality of the whole database:
- 1
- Justification:
- A factor of 1 is considered appropriate for the quality of the database.
- AF for remaining uncertainties:
- 1
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
According to the REACH "Guidance on information requirements and chemical safety assessment", a leading DN(M)EL needs to be derived for every relevant human population and every relevant route, duration and frequency of exposure, if feasible.
As HCFO 1224(yd)Z is a gas, the oral and dermal routes of exposure are considered to be not relevant, therefore no DNELs were derived for these routes.
Inhalation studies have shown HCFO 1224yd(Z) to be of an extremely low order of acute toxicity, with the 4 hour LC50 in the rat found to be in excess of 213,100ppm (1,294,114 mg/m3). However, symptoms of CNS depression were seen in rats exposed at this concentration for 4 hours. The substance is classified as STOT SE3 (H336 May cause drowsiness and dizziness). A DNEL has been derived to take account of this hazard.
Exposure of male rats to HCFO 1224yd(Z)at 20,720 ppm (125,828 mg/m3) for 90 days resulted in lower weights of the epididymides and histological alterations in the testes (atrophy of seminiferous tubule). The NOAEC for the effects was 10,320 ppm(62,671 mg/m3). A DNEL has been derived to take account of this hazard.
As no local effects were observed in either acute or long-term exposure studies, no DNELs for local effects were derived.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 224 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 224 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Corrected NOAEC = 62,671 x 6/24 x 5/7 = 11,191 mg/m3
Overall, the DNEL for long-term occupational exposure by inhalation is calculated by dividing the corrected NOAEC by the assessment factors (AF):
DNEL (long-term effects in the general population) = 11,191 / (2.5 x 10 x 2 x 1 x 1) =224 mg/m3=37 ppm
- AF for dose response relationship:
- 1
- Justification:
- A factor of 1 addresses dose response.
- AF for differences in duration of exposure:
- 2
- Justification:
- A factor of 2 is considered appropriate for exposure duration as the starting point is the NOAEC from a 90-day study.
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- 2.5 was used to address the interspecies extrapolation (toxicodynamic differences)
- AF for other interspecies differences:
- 1
- AF for intraspecies differences:
- 10
- Justification:
- 10 was considered appropriate to address the intraspecies extrapolation (general population)
- AF for the quality of the whole database:
- 1
- Justification:
- A factor of 1 is considered appropriate for the quality of the database.
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 51 765 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 51 765 mg/m³
- Explanation for the modification of the dose descriptor starting point:
No correction to the NOAEC is required to take account of differences in activity.
Overall, the DNEL for systemic effects following acute occupational exposure by inhalation is calculated by dividing the corrected NOAEC by the assessment factors (AF):
DNEL (long-term effects in the general population) = 1,294,114 /(2.5 x 10 x 1 x 1 x 1) =51,765 mg/m³ = 8,524 ppm
- AF for dose response relationship:
- 1
- Justification:
- A factor of 1 addresses dose response.
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- 2.5 was used to address the interspecies extrapolation (toxicodynamic differences)
- AF for other interspecies differences:
- 1
- AF for intraspecies differences:
- 10
- Justification:
- 10 was considered appropriate to address the intraspecies extrapolation (general population).
- AF for the quality of the whole database:
- 1
- Justification:
- A factor of 1 is considered appropriate for the quality of the database.
- AF for remaining uncertainties:
- 1
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
According to the REACH "Guidance on information requirements and chemical safety assessment", a leading DN(M)EL needs to be derived for every relevant human population and every relevant route, duration and frequency of exposure, if feasible.
As HCFO 1224(yd)Z is a gas, the oral and dermal routes of exposure are considered to be not relevant, therefore no DNELs were derived for these routes.
Inhalation studies have shown HCFO 1224yd(Z) to be of an extremely low order of acute toxicity, with the 4 hour LC50 in the rat found to be in excess of 213,100ppm (1,294,114 mg/m3). However, symptoms of CNS depression were seen in rats exposed at this concentration for 4 hours. The substance is classified as STOT SE3 (H336 May cause drowsiness and dizziness). A DNEL has been derived to take account of this hazard.
Exposure of male rats to HCFO 1224yd(Z)at 20,720 ppm (125,828 mg/m3)for 90 days resulted in lower weights of the epididymides and histological alterations in the testes (atrophy of seminiferous tubule). The NOAEC for the effects was 10,320 ppm(62,671 mg/m3). A DNEL has been derived to take account of this hazard.
As no local effects were observed in either acute or long-term exposure studies, no DNELs for local effects were derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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