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EC number: 813-937-2
CAS number: 111512-60-8
A reproduction/developmental toxicity
screening test of HCFO-1224yd(Z) was conducted in Crl:CD(SD) rats by
nose-only inhalation exposure in accordance with the OECD guideline No.
The actual exposure concentrations were
1,366,711.66 mg/m3(10,410 ppm), 2,746,552.15 mg/m3(20,920
ppm), and 5,466,846.6 mg/m3(41,640 ppm). There were no
environmental changes considered to be affecting the study results
during the exposure.
Total T4 and TSH levels in females sampled
on Day 13 of lactation were statistically significantly reduced when
compared to the levels in the controls in those exposed to 2,746,552.15
mg/m3, but not in those exposed to 1,366,711.66 mg/m3or
5,466,846.63 mg/m3. The levels in those exposed to
5,466,846.63 mg/m3tended to be low, when compared to levels
in the controls. The effect was not dose-dependent.
The normalised anogenital distance in male
offspring exposed to 5,466,846.63 mg/m3were statistically
significantly reduced when compared to the distance in controls. The
effect was slight in magnitude.
Males exposed to 5,466,846.63 mg/m3showed
reduced absolute weights of epididymides, seminal vesicles and prostate
glands when compared to the weights of the controls. Females exposed to
5,466,846.63 mg/m3showed increased absolute and relative
weights of the thyroid gland when compared to the weights of the
controls. Atrophy of the seminiferous tubule, as seen in males exposed
to 2,746,552.15 mg/m3the 90-day study, was not observed in
this study. The difference might be due to the difference in the
duration of exposure. There were no functional consequences of the
adverse pathology in males in the current study.
The effects seen in the current study,
taking into account the findings of the 90-day study, are insufficient
to warrant the classification of HCFO 1224yd(Z) for reproductive
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