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EC number: 813-937-2
CAS number: 111512-60-8
All animals survived to the scheduled necropsies. There were no test
substance-related clinical findings noted in males and females at any
No test substance-related effects on body weights, body weight gains, or
food consumption were observed in the 60,728 mg/m3 (10,000
ppm), 151,820 mg/m3 (25,000 ppm), or 242,912 mg/m3
(40,000 ppm) group males and females.
Functional observational battery parameters (home cage, handling, open
field, sensory, neuromuscular, and physiological observations) and motor
activity in males and females were not affected by test substance
exposure at any exposure concentration.
Exposure to the test substance resulted in no test substance-related
alterations in hematology, coagulation, serum chemistry, and urinalysis
parameters, organ weights, or macroscopic or microscopic findings.
Based on the results of this study, exposure to HCFO-1224yd(Z) to
Crl:CD(SD) rats at concentrations of 60,728 mg/m3 (10,000
ppm), 151,820 mg/m3 (25,000 ppm), and 242,912 mg/m3
(40,000 ppm) via nose-only inhalation for 6 hours per day on a 5-day per
week basis for 28 days resulted in no lethality or test
substance-related effects in males and females at any exposure level.
Therefore, the no-observed-effect concentration (NOEC) was considered
to be 242,912 mg/m3 (40,000ppm). The actual mean analyzed
concentration at this exposure level was 244,946 mg/m3
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