Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-092-7
CAS number: 36890-68-3
Scores of the irritation reactions after application of 0.1ml CAPA
304 to the eye of three rabbits
Region of the eye
Hours (h) after treatment
a Mean of 24, 48 and 72 hour readings
b Lacrimation with in addition a viscous clear liquid in rabbits number
2 and 3
In this eye irritation study performed according to the OECD guideline
No. 405 and in compliance with GLP, 0.1 mL of undiluted test material
was instilled into the left eye of 3 New Zealand White Male Rabbits. The
eyes were not rinsed after the instillation of the test item. The right
eye of each rabbit served as control. Animals were observed at 1, 24, 48
and 72 hours after dosing under a standard light source. The reactions
in the conjunctiva (redness, chemosis and discharge), the iris and the
cornea (opacity and area involved) were scored according to the Draize
No corneal or iridial effects were noted during the study. Very slight
irritation of the conjunctiva and lacrimation was observed in 3 rabbits
1 hour after instillation of 0.1 ml CAPA 304 in their left eye. This
effect however disappeared after 24hrs. The calculated mean score for
redness, discharge, chemosis, iris and corneal lesions for all animals
at 24, 48 and 72h after treatments was 0. One hour after instillation of
the test material; discharge of any amount different from normal (does
not include small amount observed in inner canthus of normal animals)
was noticed in all animals. Lacrimation and with addition a viscous
clear liquid in rabbits number 2 and 3. The effects observed 1hr after
instillation was test material disappeared after24 hours.
Under the test conditions, the test material is not
classified as irritating to eyes according to the criteria of the Annex
VI of the Regulation (EC) No 1272/2008 (CLP)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Questo sito web si avvale di cookie affinché possiate usufruire della migliore esperienza sui nostri siti web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again