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EC number: 500-092-7
CAS number: 36890-68-3
oligomeric reaction products with 2,2' oxydiethanol has been tested for
skin irritation and eye irritation in rabbits in studies conducted to
OECD Test Guidelines 404 and 405 respectively. The substance was not
found to be irritating to the skin or the eyes and no classification in
respect of these endpoints is required.
The dermal irritation potential of ε-Caprolactone,
oligomeric reaction products with 2,2' oxydiethanol (CAPA 304) was
investigated in a study performed according to OECD guideline 404. 0.5 g
test material was applied on the clipped skin of 3 New Zealand White
male rabbits for 4 hours. Animals were observed at 30-60 minutes and at
24, 48 and 72 hours after patch removal for oedema and erythema. The
mean scores calculated for each individual animal tested for erythema
and oedema at 24, 48 and 72 hours was 0. No dermal irritation was
The eye irritation potential of ϵ-caprolactone, oligomeric reaction
products with 2,2’-oxydiethanol (CAPA 304) was investigated in a study
performed according to OECD guideline 405. 0.1 mL test material was
instilled into the left eye of three New Zealand White rabbits. Animals
were observed at 1, 24, 48 and 72 hours after dosing under a standard
light source. The reactions in the conjunctiva (redness, chemosis and
discharge), the iris and the cornea (opacity and area involved) were
scored according to the Draize scale. No corneal or iridial effects were
noted during the study. Very slight irritation of the conjunctiva and
lacrimation was observed in 3 rabbits 1 hour after instillation. This
effect disappeared after 24 hours. The calculated mean score for
redness, discharge, chemosis, iris and corneal lesions for all animals
at 24, 48 and 72h after treatments was 0.
The substance was found to be non-irritating to the skin in a study
conducted according to OECD 404 and was non-irritating to the eyes in a
study conducted according to OECD 405. Classification for skin or eye
irritation is not required according to the criteria of the Annex VI of
the Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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