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EC number: 500-092-7 | CAS number: 36890-68-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
ε-Caprolactone, oligomeric reaction products with 2,2' oxydiethanol has been tested for skin irritation and eye irritation in rabbits in studies conducted to OECD Test Guidelines 404 and 405 respectively. The substance was not found to be irritating to the skin or the eyes and no classification in respect of these endpoints is required.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The dermal irritation potential of ε-Caprolactone, oligomeric reaction products with 2,2' oxydiethanol (CAPA 304) was investigated in a study performed according to OECD guideline 404. 0.5 g test material was applied on the clipped skin of 3 New Zealand White male rabbits for 4 hours. Animals were observed at 30-60 minutes and at 24, 48 and 72 hours after patch removal for oedema and erythema. The mean scores calculated for each individual animal tested for erythema and oedema at 24, 48 and 72 hours was 0. No dermal irritation was observed.
Eye irritation
The eye irritation potential of ϵ-caprolactone, oligomeric reaction products with 2,2’-oxydiethanol (CAPA 304) was investigated in a study performed according to OECD guideline 405. 0.1 mL test material was instilled into the left eye of three New Zealand White rabbits. Animals were observed at 1, 24, 48 and 72 hours after dosing under a standard light source. The reactions in the conjunctiva (redness, chemosis and discharge), the iris and the cornea (opacity and area involved) were scored according to the Draize scale. No corneal or iridial effects were noted during the study. Very slight irritation of the conjunctiva and lacrimation was observed in 3 rabbits 1 hour after instillation. This effect disappeared after 24 hours. The calculated mean score for redness, discharge, chemosis, iris and corneal lesions for all animals at 24, 48 and 72h after treatments was 0.
Justification for classification or non-classification
The substance was found to be non-irritating to the skin in a study conducted according to OECD 404 and was non-irritating to the eyes in a study conducted according to OECD 405. Classification for skin or eye irritation is not required according to the criteria of the Annex VI of the Regulation (EC) No 1272/2008 (CLP).
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