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EC number: 500-092-7
CAS number: 36890-68-3
In this dermal irritation study performed according to the OECD
guideline No. 404, and in compliance with GLP, 0.5 g of CAPA 304 was
applied on the clipped skin of 3 New Zealand White male rabbits.
The patches were sustained by occlusive Blenderm tape and secured in
place by adhesive tape. The animals were fitted with Elizabethan collars
in order to prevent disturbance of the application for 4 hours. After
this period, the collars and patches were removed and the skin was wiped
to remove any remaining test substance.
Animals were then observed 30-60 minutes and at 24, 48 and 72 hours
after patch removal for oedema and erythema and skin irritation was
assessed. The mean scores calculated for each individual animal tested
for erythema and oedema at 24, 48 and 72 hours was 0. No dermal
irritation was observed.
Under the test conditions, the test material is not
classified as a skin irritant according to the Annex VI of the
Regulation (EC) No. 1272/2008 (CLP).
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