Registration Dossier
Registration Dossier
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EC number: 624-182-1 | CAS number: 4187-38-6
Endpoint summary
Administrative data
Description of key information
(S)-1-(3-Methoxyphenyl)ethylamine (read across, CAS 82796-69-8) had a sensitizing effect on the skin of the guinea pig in the Maximization Test (OECD 406).
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See chap. 13 read across justification
- Reason / purpose for cross-reference:
- read-across source
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- vehicle control
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: vehicle control. No with. + reactions: 0.0. Total no. in groups: 5.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- vehicle control
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: vehicle control. No with. + reactions: 0.0. Total no. in groups: 5.0.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
(S)-1-(3-Methoxyphenyl)ethylamine (read across, CAS 82796-69-8) was tested for its sensitizing effect on the skin of the guinea pig in the Maximization Test based on the method of Magnusson and Kligman. The study was performed using one control group and one test group. Based on the results it was concluded, that (S)-1-(3-Methoxyphenyl)ethylamine showed a strong sensitizing potential. [BASF, 2008]
Justification for classification or non-classification
Based on the available data for (S)-1-(3-Methoxyphenyl)ethylamine (read across, CAS 82796-69-8) (R)-1 -(4 -Methylphenyl)ethylamine is
subject to C&L:
according to Regulation 1272/2008/EC: sensitizing cat. 1A, H317
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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