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EC number: 624-182-1
CAS number: 4187-38-6
The potential of rac-1-(3-Methoxyphenyl)ethylamine to cause dermal
corrosion was assessed by a single topical application of 50 μL of the
test substance to a reconstructed three dimensional human epidermis
model (EpiDerm™). Two EpiDerm™ tissue samples were incubated with the
test substance for 3 minutes and 1 hour, each. Tissue destruction was
determined by measuring the metabolic activity of the tissue after
exposure using a colorimetric test. The reduction of mitochondrial
dehydrogenase activity, measured by reduced formazan production after
incubation with a tetrazolium salt (MTT) was chosen as suitable
endpoint. The formazan production of the test-substance treated
epidermal tissues is compared to that of negative control tissues. The
quotient of both values indicates the
relative tissue viability. The EpiDerm skin corrosivity test showed the
The test substance is able to directly reduce MTT. However, this ability
of direct MTT reduction did not impair the study result as demonstrated
by the concurrently performed exposure of control tissues inactivated by
freezing. Viability of the test-substance treated tissues determined
after an exposure period of 3 minutes was 92%. Viability of the
test-substance treated tissues determined after an exposure period of 1
hour was 9%. Based on the observed results and applying the evaluation
criteria it was concluded, that rac-1-(3-Methoxyphenyl)ethylamine shows
a corrosive potential in the EpiDerm™ skin corrosivity test under the
test conditions chosen. The test method does not yet allow for the
differentiation of severity of the effect. The results however indicate
moderate corrosivity. For final assignment of a risk phrase at present,
further evidence or results from an in vivo study would be needed.
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