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EC number: 624-182-1
CAS number: 4187-38-6
The evaluation depends on the solubility of the test substance, the
tested concentrations and the time until appearance of unambiguous
intravascular coagulation of middle-sized vessels or extravascular
coagulation of the treated CAM, respectively. The mean time until
appearance of reaction over the eggs of a treatment group was calculated
(mean time to coagulation = mtc in seconds):
mtc(100%) < 90 "risk of serious damage to the eyes"
mtc(100%) x 0.019 + mtc(10%) x 0.017 < 4.404 "risk of serious damage to
mtc(100%) ≥ 90 "no risk of serious damage to the eyes"
0 No visible change
1 Slight reaction
2 Moderate reaction
3 Severe reaction
The potential of rac-1-(3-Methoxyphenyl)ethylamine to cause serious
damage to the eyes/mucous membranes was assessed by a single topical
application of 0.3 mL of the undiluted test substance and 0.3 mL of a
10% test-substance solution in olive oil Ph.Eur./DAB, to the
chorionallantoic membrane (CAM) of fertilized and incubated hen eggs.
Three eggs per test-substance concentration were observed until
unambiguous irritation reactions were detected or up to a maximum time
period of 210 seconds. The occurrence of vascular injury or
intravascular coagulation in response to the test substance was
recorded. The undiluted test substance caused severe intravascular as
well as extravascular coagulation and moderate haemorrhagia in all eggs
within 9 – 12 seconds after application. The 10% test substance solution
in olive oil Ph.Eur./DAB caused moderate intravascular coagulation in
all eggs after 49 – 85 seconds and moderate haemorrhagia in all eggs
within 11 – 17 seconds. Based on the results of this study it was
concluded, that rac-1-(3-Methoxyphenyl)ethylamine causes serious eye
damage in the HET-CAM Test under the test conditions.
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