Registration Dossier
Registration Dossier
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EC number: 624-182-1 | CAS number: 4187-38-6
Endpoint summary
Administrative data
Description of key information
The oral LD50 of rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) was between 300 and 2000 mg/kg bw (OECD 423).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See chap. 13 read across justification
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- act. ingr.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Additional information
The acute oral toxicity of rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) was determined to be 300 -2000 mg/kg bw (OECD 423). Thus, in accordance to the GHS (Globally Harmonised System), the substance (R)-1-(4-Methylphenyl)ethylamine should be classified in the hazard category 4.
Justification for classification or non-classification
Based on the available data for rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) (R)-1-(4-Methylphenyl)ethylamine is subject to C&L:
according to Regulation 1272/2008/EC: acute oral tox. 4, H302
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