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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The oral LD50 of rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) was between 300 and 2000 mg/kg bw (OECD 423).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
See chap. 13 read across justification
Reason / purpose for cross-reference:
read-across source
Dose descriptor:
Effect level:
> 300 - < 2 000 mg/kg bw
Based on:
act. ingr.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed

Additional information

The acute oral toxicity of rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) was determined to be 300 -2000 mg/kg bw (OECD 423). Thus, in accordance to the GHS (Globally Harmonised System), the substance (R)-1-(4-Methylphenyl)ethylamine should be classified in the hazard category 4.

Justification for classification or non-classification

Based on the available data for rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) (R)-1-(4-Methylphenyl)ethylamine is subject to C&L:

according to Regulation 1272/2008/EC: acute oral tox. 4, H302