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EC number: 271-089-3
CAS number: 68515-47-9
Minimally Toxic. Based on test data for the material.
The High Molecular Weight Phthalate Ester (HMWPE) Category consists of
phthalate esters with an alkyl carbon backbone with 7 carbon (C7) atoms
or greater. The category is formed on the principle that substances of
similar structure have similar toxicological properties. The data
available on high molecular weight phthalates demonstrate that members
of this category have similar biological activities and toxicological
properties; verifying the use of read-across data as an appropriate
approach to characterize endpoints. DTDP (C13) is a
high molecular weight phthalate ester. Where data
maybe lacking for DTDP, DINP (C9) and DIDP (C10), which are also high
molecular weight phthalate esters, are used as read-across substances to
provide toxicological information.
Like other high molecular weight phthalate esters, DTDP was observed to
have a low order of toxicity by the dermal and oral routes of exposure
in acute toxicity animal studies (ExxonMobil., 1981a,b; Sasol Germany
GmbH, 1984). For example, in oral studies, no significant signs of
toxicity are reported, even in studies using doses well above the limit
dose recommended by current regulatory guidelines (2000 mg/kg). In
dermal studies, limited reversible irritation is the only effect
associated with treatment.
Due to their low vapor pressures and the technical difficulties of
generating a vapor at ambient temperatures, few studies by the
inhalation route of exposure for any high molecular weight phthalate are
available, most of which are relatively old and conducted before the
development of testing guidelines or the implementation of good
laboratory practice procedures. Although poorly documented, there were
no reports of body weight changes, gross lesions or microscopic
alterations of lungs; only slight tearing of the eye and slight clear
nasal discharge when animals were exposed to DINP at the saturated vapor
concentration. As reported in the European Union Risk Assessment for
DINP, the LC50 for an aerosol is greater than 4.4 mg/l (European
Commission). It is expected that DTDP would exhibit
These data taken together with data from structurally similar compounds
suggest that DTDP has a low potential for acute toxicity.
No classification for acute toxicity is indicated according to the
general classification and labeling requirements for dangerous
substances and preparations (Directive 67-548-EEC) or the
classification, labeling and packaging (CLP) regulation (EC) No
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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