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EC number: 271-089-3
CAS number: 68515-47-9
Long-term toxicity to fish:Conclusion: Results of studies with two analog substances suggest that DTDP will not produce chronic toxicity to fish at or below its maximum attainable water solubility.
result of a long-term toxicity study is reported as a NOEC value for
chronic fish toxicity. The NOEC value from these studies represents the
highest concentration tested and measured under the conditions of the
from a long-term fish toxicity studies show that DIDP and
Diundecylphthalate (DUP), analogs to DTDP, do not cause toxicity
(ExxonMobil, 2002; Rhodes et al., 1995). Additionally, the results can
be used to assess the potential for endocrine disruption in fish.
multi-generation feeding study with Oryzias latipes (Medaka, 284-days)
was conducted by adding DIDP to dry flake food at 20 mg/kg. Evaluation
of F1 and F2 embryos showed normal development except for a transient
decrease in red blood cell pigmentation, which was observed in both the
acetone control and DIDP treatment groups. The male to female ratios
(3:1) in all groups were similar. Phenotypic gender classification of
male and female fish was histopathologically confirmed to be 100%
correct. The gonadal and liver somatic indices were not significantly
different in the DIDP treated group. There were no statistically
significant changes in mortality, fecundity, or egg production in the
showed no effect on egg hatchability, egg survival, fry survival, or
growth (length and weight) at its highest achievable water solubility
(0.30 mg/L) under the conditions of this test. No
compound-related physical and behavioral effects were noted at any test
The data used to characterize the fish
chronic toxicity of di-isotridecyl phthalate (DTDP) ester are consistent
with the data for several high molecular weight phthalate diesters
summarized by Staples et al. (1997). These data show that high molecular
weight phthalate diesters do not produce chronic toxicity to fish at or
below their maximum attainable solubliity. The data used to characterize
DTDP are for diundecyl phthalate ester (DUP) and di-isodecyl phthalate
ester (DIDP), which are analogs to DTDP. Results of studies with two
analog substances suggest that DTDP will also not produce chronic
toxicity to fish at or below its maximum attainable solubility. Because
of the structural similarity between these substances and the similar
biological behavior of high molecular weight phthalate esters in
general, data for the analogs can be used to characterize the biological
effects of DTDP for this endpoint. The chronic fish dataset includes
results for two species of freshwater fish, Oncorhynchus mykiss and
Staples et al. (1997). Aquatic toxicity of
eighteen phthalate esters. Environ. Toxicol. Chem. 16(5): 875 -891.
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