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EC number: 252-744-2
CAS number: 35836-73-8
an acute dermal toxicity study performed similarly to Guideline OECD
402, groups of rabbits (2 to 8 animals/dose) were given a single dermal
application of Nopol at 2500 (2 animals) and 5000 (8 animals) mg/kg bw.
Animals were observed for mortality and clinical signs for 3 days.
to moderate erythema and edema were noticed throughout the observation
period. Ataxia, ptosis and piloerection were observed at 5000 mg/kg bw. The
dermal LD50 of the test item was considered to be higher than 5000 mg/kg
bw in rabbits.
The acute dermal LD50 of Nopol is higher
than 2000 mg/kg bw in rabbits therefore it is not classified according
to CLP Regulation (EC) N° 1272/2008 and GHS.
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