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EC number: 222-048-3
CAS number: 3327-22-8
2-Chloro-2-hydroxypropyl-trimethylammonium chloride caused minimal
hyperkeratosis and acanthosis, but no local tumors at the site of
application. However, an increased incidence of tumors and hyperplasia
in the lungs of the animals seems to be a treatment related effect. The
interpretation of these findings is difficult because the duration of
the current study was considerably longer than the average study
duration in published historic data of the same mouse strain.
Additionally, even if the slightly increased tumor incidence represents
a real effect, its biological significance is unclear and may represent
a promoting effect rather than a tumor inducing phenomenon. The
slight increased incidence of glandular hyperplasia of the stomach seen
in high dose group may be due to unintended oral uptake of the test
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