Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-048-3 | CAS number: 3327-22-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-12-09 to 1998-01-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- Directive 92/69/EEC, A.8.
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < -1.5
- Temp.:
- 25 °C
- pH:
- 3.9
- Details on results:
- The partition coefficient (1-octanol/buffered water phase, pH4) of the test item was calculated as mean value from all single results. The pH value of the buffer solution was 3.95.
- Conclusions:
- A log Pow value of lower than -1.5 was determined at pH 3.9 and 25°C in a reliable study conducted according to EU method A.8.
- Executive summary:
The partition coefficient octanol/water of the test item was determined according to EU method A.8 and is < 1.5 at pH 3.9 and 25 °C.
Reference
Test No. (O/W) |
concentration of test substance in the 1-octanol phase [mg/l] |
concentration of test substance in the 1-octanol phase [mg/l] |
Pow |
mean value Pow |
pH-value of aqueous phase |
A (1/3) |
<50 |
1615.8758 |
<0.03094 |
<0.03095 |
3.92 |
B (1/3) |
<50 |
1614.7795 |
<0.03096 |
3.95 |
|
C (1/1) |
<50 |
1583.8554 |
<0.03157 |
<0.03129 |
3.95 |
D (1/1) |
<50 |
1612.8268 |
<0.03099 |
3.94 |
|
E (3/1) |
<50 |
1634.4181 |
<0.03059 |
<0.03079 |
3.95 |
F (3/1) |
<50 |
1613.6414 |
<0.03099 |
3.95 |
|
Blank(1/1) |
----- |
----- |
----- |
----- |
3.94 |
Description of key information
The log Pow of the test item is < -1.5 at pH 3.9 and 25 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.5
- at the temperature of:
- 25 °C
Additional information
The partition coefficient octanol/water of the test item was determined according to EU method A.8.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
