Registration Dossier
Registration Dossier
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EC number: 245-904-8 | CAS number: 23843-64-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No studies are available. Based on molecular structure, molecular weight, water solubility, vapour pressure and octanol-water partition coefficient it can be expected that the substance is likely to be absorbed via the inhalation, dermal and oral route. Hydrolysis is expected to occur rapidly, and based on the physico-chemical parameters of the silanol containing degradation product, absorption via the gastrointestinal tract and to a lesser extend via the dermal and inhalation route are expected. Due to the high water solubility, the hydrolysis product is expected to be widely distributed in the body. Excretion via the renal route is considered favoured, and test material deposited in the stratum corneum is expected to be sloughed off with the skin cells. Thus, bioaccumulation is expected to be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
There are no studies available in which the toxicokinetic properties of 1-[3-(trimethoxysilyl)propyl]urea (CAS 23843-64-3) have been investigated. Therefore, the toxicokinetic behavior assessment of the substance and its hydrolysis product was estimated by its physico-chemical properties and the available toxicology studies on the substance itself. Based on molecular structure, molecular weight, water solubility, vapour pressure and octanol-water partition coefficient it can be expected that the substance is likely to be absorbed via the inhalation, dermal and oral routes. Hydrolysis is expected to occur rapidly, and based on the physico-chemical parameters of the silanol degradation product, absorption via the gastrointestinal tract and to a lesser extend via the dermal and inhalation route are expected. Due to the high water solubility, the hydrolysis product is expected to be widely distributed in the body. Excretion via the renal route is considered favoured, and test material deposited in the stratum corneum is expected to be sloughed off with the skin cells. Thus, bioaccumulation is expected to be low. The detailed toxicokinetic behaviour assessment of the substance and its hydrolysis products is attached to this section.
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