Registration Dossier
Registration Dossier
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EC number: 245-904-8 | CAS number: 23843-64-3
Endpoint summary
Administrative data
Description of key information
Additional information
The registered (parent) substance 1 -[3 -(trimethoxysilyl)propyl]urea (CAS No. 23843-64-3) hydrolyses rapidly under environmental relevant conditions (DT50 (pH 7) = 2.8 h at room temperature) to form the silanol hydrolysis product [3 -(trihydroxysilyl)propyl]urea and the alcohol hydrolysis product methanol.
The ECHA guidance R.16 states that “for substances where hydrolytic DT50 is less than 12 h, environmental effects are likely to be attributed to the hydrolysis product rather than to the parent itself” (ECHA, 2016). The ECHA guidance R.16 also suggests that in cases where the hydrolysis half-life is less than 12 h, the breakdown products, rather than the parent substance, should be evaluated for aquatic toxicity. Thus, the environmental fate assessment in this dossier is based on the hydrolysis products.
The parent substance is characterized by a predicted water solubility of 2.4E+05 mg/L (at 20 -25°C, QSAR) and is not readily biodegradable (OECD 310). It has a low predicted vapour pressure of 2.8E-02 Pa (25°C, QSAR) and thus exhibits low volatility. Therefore, indirect photodegradation is not an important degradation pathway. Furthermore, it has a low predicted log Kow of -0.2 (QSAR), indicating a low potential for adsorption to soil and sediment.
Silanol hydrolysis product [3-(trihydroxysilyl)propyl]urea (CAS No. not available)
The silanol hydrolysis product is characterized by a predicted water solubility of 1.0E+06 mg/L (20 -25°C, QSAR) and a very low predicted vapour pressure of 4.1E-07 Pa (25°C, QSAR), indicating low volatility. Therefore, indirect photodegradation is not an important degradation pathway. There is no evidence of any significant biodegradation. However, its potential for bioaccumulation and its affinity to soil and sediment is low based on its low, predicted log Kow of -3.3 (QSAR).
Methanol (CAS No. 67 -56 -1)
The main target compartment of environmental methanol is air (73%) and water (16%) based on fugacity model calculations. Methanol is miscible with water at 20 °C, does not undergo hydrolysis and volatilization is not a significant removal process from the aquatic compartment (HLC = 0.461 Pa m3/mol, VP = 128 hPa). However, methanol is readily biodegradable and has a low potential for bioaccumulation (log Kow = -0.74). Its toxicity toward aquatic organisms is low, with acute toxicity values of well above 1000 mg/L. Overall, methanol is considered to have a low environmental hazard profile.
Source: OECD SIDS Initial Assessment Profile, SIAM, 2004
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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