[3-(trimethoxysilyl)propyl]urea

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the attached justification in IUCLID Section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Description of key information

LC50 (96h) > 100 mg/L (nominal, OECD 203, RA CAS No. 116912-64-2)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

LC50

Effect concentration:

> 100 mg/L

Additional information

No reliable data on the toxicity of 1-[3-(trimethoxysilyl)propyl]urea (CAS No. 23843-64-3) to fish are available. Therefore, good quality data from the analogous substance, ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (CAS No. 116912-64-2), have been read across. Details on read across justifications can be found in IUCLID Section 13.

 

In a study (NOTOX 2000) according to the guideline OECD 203 and GLP standards, the short term toxicity of the read across substance ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (CAS No. 116912-64-2) to fish was tested. Cyprinus carpio as the test organism was exposed under static conditions for 96 h to the single nominal test item concentration of 100 mg/L. The substance was tested in a static system due to its high rate of hydrolytical degradation. With a static system an exposure to both the parent and the hydrolysis products was achieved. The substance was analytically monitored at the time points 0, 48 and 96 h. No toxic effects were observed in the study resulting in an LC50 (96 h) of > 100 mg/L (nominal).