Registration Dossier
Registration Dossier
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EC number: 245-904-8 | CAS number: 23843-64-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Reference
Description of key information
EC50 (48h) > 100 mg/L (nominal, OECD 202, RA CAS No. 116912-64-2)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
No reliable data on the toxicity of 1-[3-(trimethoxysilyl)propyl]urea (CAS No. 23843-64-3) to aquatic invertebrates are available. Therefore, good quality data from the analogous substance, ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (CAS No. 116912-64-2), have been read across. Details on read across can be found in IUCLID Section 13.
In a study (2000) according to the guideline OECD 202 and GLP standards, the short term toxicity of the read across substance ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (CAS No. 116912-64-2) to aquatic invertebrates was tested. Daphnia magna as the test organism was exposed under static conditions for 48 h to a single nominal test item concentration of 100 mg/L and a blank control. The substance was analytically monitored and samples were collected at the beginning and at the end of the experiment. The substance degraded rapidly within 48 h due to hydrolysis. No toxic effects were observed in the study resulting in an EC50 (48 h) of > 100 mg/L (nominal). The substance was tested in a static system due to its high rate of hydrolytical degradation. With a static system an exposure to both the parent and the hydrolysis products was achieved while none caused toxic effects to fish. The result is considered to be reliable.
No toxic effects to aquatic invertebrates are expected by 1 -[3 -(trimethoxysilyl)propyl]urea (CAS No. 23843-64-3) based on the results obtained for the read across substance.
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