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EC number: 292-697-5
CAS number: 90989-41-6
Groups of 10 or 15 rats/sex were
administered 0, 25, 50, 100, 200, 400 or 600 mg/kg benzene in corn oil
by gavage, 5 days/ week for 17 weeks. Five rats/sex were killed on days
0 and 60 from the 0, 200, and 600 mg/kg groups, remaining surviving
animals were killed on day 120. Clinical observations, bodyweights, food
consumption, haematological analyses and histopathological examinations
were performed. No compound-related deaths occurred. Final mean body
weights (relative to those of the vehicle controls) were depressed
14%-22% for male and female rats that received ≥200 mg/kg benzene. A
dose-related leukopenia and lymphocytopenia was observed in males at
≥200 mg/kg and in females at ≥25 mg/kg. In the spleen, lymphoid
depletion of B-cells was observed in both sexes at ≥200 mg/kg benzene
and increased extramedullary haematopoiesis was observed 600 mg/kg.
NOAEL for males was 100 mg/kg/day. LOAEL for
males was 200 mg/kg and for females was 25 mg/kg/day.
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