Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 292-697-5
CAS number: 90989-41-6
Groups of 10 or 15 rats/sex were
administered 0, 25, 50, 100, 200, 400 or 600 mg/kg benzene in corn oil
by gavage, 5 days/ week for 17 weeks. Five rats/sex were killed on days
0 and 60 from the 0, 200, and 600 mg/kg groups, remaining surviving
animals were killed on day 120. Clinical observations, bodyweights, food
consumption, haematological analyses and histopathological examinations
were performed. No compound-related deaths occurred. Final mean body
weights (relative to those of the vehicle controls) were depressed
14%-22% for male and female rats that received ≥200 mg/kg benzene. A
dose-related leukopenia and lymphocytopenia was observed in males at
≥200 mg/kg and in females at ≥25 mg/kg. In the spleen, lymphoid
depletion of B-cells was observed in both sexes at ≥200 mg/kg benzene
and increased extramedullary haematopoiesis was observed 600 mg/kg.
NOAEL for males was 100 mg/kg/day. LOAEL for
males was 200 mg/kg and for females was 25 mg/kg/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again