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EC number: 292-697-5
CAS number: 90989-41-6
Female SD rats, age approx. 7 weeks, were
exposed (whole body) to ethylbenzene vapour (0, 25, 125 and 500 ppm) for
28-d and humoral immune function determined using splenic
antibody-forming cell (AFC) plaque-forming assay following sensitisation
of the animals to sheep red blood cells (sRBC). A positive control group
received cyclophosphamide.The assay assesses the interaction of
complement and antibodies (produced in response to immunization) that is
directed against sRBC. The study design and conduct was OPPTS 870.7800
compliant, with the results providing a measure of the effect of
ethylbenzene on humoral immune responses. The results showed that spleen
and thymus weights from ethylbenzene-exposed animals were unremarkable,
with no treatment-related effects on spleen cell number or IgM AFC
responses in sRBC-sensitised animals. In contrast spleen and thymus
weights, together with specific and total IgM AFC, were clearly and
significantly reduced after cyclophosphamide treatment. The results
demonstrate that sub-acute exposure to up to 500 ppm ethylbenzene vapour
for 28 -d was without effect on the humoral component of the rat immune
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