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EC number: 292-697-5
CAS number: 90989-41-6
SIGNS AND MORTALITY: No mortality, all rats remained in good health.
WEIGHT AND WEIGHT GAIN: No statistically significant differences.
EXAMINATION: No effect on the latency or amplitudes of brainstem
auditory evoked responses or audiometric thresholds.
STUDY: There was no loss of hair cells either in the inner or outer hair
cell rows of the organ of Corti.
Sprague-Dawley rats were exposed to m-xylene by inhalation (0, 450, 900
and 1800ppm, 6 hr/day, 5 days/week for 13 weeks) and brainstem
auditory-evoked responses were determined 8 weeks after treatment ended.
The cochlea and organ of Corti were examined using light or electron
microscopy, respectively. No functional or structural alterations were
present, with an overall NOAEC of >=1800 ppm for ototoxicity.
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