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EC number: 292-697-5
CAS number: 90989-41-6
Observed Deaths* and SMRs 1950-1996 in Rubber Hydrochloride Workers
Exposed to at Least 1 ppm-day of Benzene (Table based on Rinsky et al,
2002; Table III).
All subjects (n=1291)
White males (n=1165)
SMR (95% CI)
All malignant neoplasms
Lymphatic and haematopoietic cancers combined:
begins in 1950 and expected deaths are based on U.S. population rates
1950-1996 for all outcomes except multiple myeloma and non-Hodgkin
multiple myeloma and NHL, risk begins in 1960, the first year separate
rates are available. Expected deaths for these outcomes are based on
1960-1996 U.S. rates.
2. SMRs for Leukaemia in White Males Exposed to Benzene, by Exposure
Category(Table based on Rinsky et
al, 2002; Table IV).
1 ppm day-30.99 ppm-years
40 - 199.99 ppm-years
200 - 399.99 ppm-years
> 400 ppm-years
A cohort of rubber hydrochloride workers has
been investigated in an update of a retrospective cohort mortality
The latest findings reaffirm the
leukaemogenic effects of benzene exposure. Only 1 new leukaemia death
had occurred in the additional 9 years of follow up and the study
suggests that excess risk diminishes with time. Risk estimates such as
Crump (1994) based on the previous update would be unlikely to change
much if they incorporated additional follow up information from the
latest update of the cohort mortality study.
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