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EC number: 292-697-5
CAS number: 90989-41-6
No exposure-related mortality or effects on
mean body weight and clinical signs were seen. Female rats of the 30 ppm
dose group showed lower thyroid weight on day 14 only. At 300 ppm
statistically significant decreases in WBC counts were seen in males on
day 14 and females on day 91; statistically significant decreases in
percent lymphocytes were noted in both males and females on days 14, 28,
56 and 9 (no further detail provided). At this same dose level decreased
femoral marrow cellularity was seen on day 7 only.
A subchronic inhalation toxicity study of
benzene was conducted in Sprague-Dawley rats. Four groups of animals
consisting of 50 rats/sex each were exposed to concentrations of 0, 1,
10, 30, and 300 ppm (0, 3.2, 9.6, 960 mg/m3) benzene vapour,
6 h/day, 5 days/week, for 13 weeks. Ten rats/sex in each group were
sacrificed after 7, 14, 28, 56, and 91 days of treatment. Criteria used
to evaluate exposure-related effects included behaviour, bodyweights,
organ weights, clinical pathology, gross pathology, and histopathology.
No consistent exposure-related trends were
seen in the clinical observations and bodyweight data. Exposure-related
clinical pathology changes were seen in the high-level (300 ppm)
animals. Decreased lymphocyte counts and a relative increase in
neutrophil percentages were the only exposure-related clinical pathology
alterations. The only exposure-related lesion consisted of slightly
decreased femoral marrow cellularity in the animals exposed to 300 ppm.
The NOAEC for toxicity at 28 and 90 days was
30 ppm (96 mg/m3) for both male and female rats.
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