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EC number: 213-022-2
CAS number: 915-67-3
Table 1: Summary of data of litters in F1 generation study of
Amaranth Administered in mice
Dose Levels (%)
No of litter
No of pups
Pup Weight (g)
Litter Weight (g)
Eacch value represents mean± S.D
The color additive, amaranth, was
given in the diet to provide dietary levels of 0 (control), 0.03,0.09 and
0.27%, from 5 weeks of age in F0,
generation mice to 9 weeks of age in F1, generation mice, and some
reproductive, developmental and
behavioral parameters were measured.
and female mice (Crj:CD-1, 4 weeks old) were obtained from Charles River
Japan Inc. (Tokyo, Japan). They were individually housed in
polycarbonate solid floored cages with wood flakes. They were given
control or experimental diets and water ad libitum. Amaranth was
administered in the diet to 60 mice (IO/sex/group) at dietary levels of
0.03, 0.09 and 0.27%. The 20 mice (lo/sex) in the control group were
given the basal diet (Nihon Clea, CE-2) for a corresponding period of
time The animals were 5 weeks old at the start of the study. At 8 weeks
of age, the motor activity of the mice was measured by an animal
movement analyzing system (ANIMATE AT-420, Toyo Sangyo Co., Ltd, Toyama,
Japan).At 9 weeks of age, each female was paired with one male from the
same treatment group, for a period of 5 days. After 5
the males were removed from the females, and the females were allowed to
produce and rear their pups.
postnatal day 0 (PND 0), litter size, pup weight, and litter weight were
measured. The pups were weighed on PND 4, 7, 14 and 21 during the
lactation period. The physical and functional developmental parameters
were measured for individual pups, and were analyzed on a whole-litter
basis as follows:
righting (PND 4 and 7)
geotuxis (PND 4 and 7)
Cliff avoidance (PND 7)
(PND 4, 14)
orientation (PND 14)
t-test was performed on litter size, pup weight, and litter weight. The
behavioral parameters were assessed with the Mann-Whitney U-test.
was no consistent significant compound- or dose-related effect in motor
activity of mice administered amaranth.There was no
effect on the parameters of litters, litter size, pup weight and litter
weight. The body weight of pups during the lactation period in the
treatment groups increased less significantly, and the survival index at
postnatal day (PND) 21 of the amaranth 0.27% group was reduced.The
developmental parameters were repressed in the amaranth 0.03% group
(about 50 mg/kg/d)
The dose levels of amaranth
influenced some reproductive, developmental and behavioral parameters in
Observed Effect Level in maternal and F1 generation mice after
administration of Amaranth
dye was0.03% (about 50 mg/kg/day).
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