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EC number: 213-022-2
CAS number: 915-67-3
Table 1: Chromosomal aberrations of
mice bone marrow cells following treatment with different doses of
Type of Aberrations
Where: G’ G’’ = Chromatid and
B’ B’’ = Chromatid and chromosome breaks
RR = rearrangements,
DC = Percentage of damaged cells
Chromosome aberration assay was
performed to evaluate the mutagenic nature of the test compound amaranth.
was conducted on male Swiss albino mice, 8-10 weeks old and weighing
20-25 g. Four animals per dose were administered intraperitoneally with
the different doses of the amaranth (50,100 and 200 mg/kg body weight).
were killed after 18 hr. For bone marrow chromosome analysis, animals
were injected with 0.1 ml colchicine solution (4mg/10ml distilled water
/10g body weight, 90 minutes before they were killed. Bone marrow cells
were routinely processed by the standard procedure and slides were coded
and stained in diluted Giemsa.
chromosomal aberration analysis, four animals were used per point.
Hundred well spread metaphase plates were scored per animal (400
metaphase plates per treatment set) at random. The types of aberrations
were scored. The percentages of damaged cells (% DC) and chromosomal
aberrations per cell (CA/cell) values were calculated excluding gaps.
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