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EC number: 265-058-3
CAS number: 64741-57-7
A complex combination of hydrocarbons produced by the vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and boiling in the range of approximately 350°C to 600°C (662°F to 1112°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
No data on the oral and inhalation are available or required given that
the dermal route is the most plausible route of exposure to Heavy Fuel
Changes in haematological and clinical chemistry parameters and organ
weight/s have been reported post dermal exposure to Heavy Fuel Oil
Components. In general, alterations in serum cholesterol and blood urea
nitrogen were recorded following administration of higher dermal doses
accompanied by red cell, platelet, liver and thymus effects at lower
from a series of GLP-compliant sub-acute studies of up to 28 days
duration in rats and rabbits indicate the occurrence of
treatment-related irritation in some, but not all, studies. Comparable
findings were also observed following sub-chronic exposure and indicate
that more extended exposure (i.e. 90 days versus 28 days) did not lead
to any progression in severity of this effect (Feuston, 1994, 1997;
ARCO, 1994d; Mobil, 1995a, 1994a,b, 1992e, 1985a, 1988l; API, 1985a, and
findings in the rat following 28 days repeated dermal exposure to Heavy
Fuel Oil Components included decreased body weight, increased liver
weight (sometimes with accompanying microscopic changes) and alterations
in haematological and clinical chemistry parameters (ARCO, 1994c; 1993c;
1992ab-ad, af-ag; 1990j; 1988c; 1987g,h; API, 1986a; 1983a). 28-day
dermal exposure to Heavy Fuel Oil Components has also been demonstrated
to adversely affect the liver of rabbits (API, 1980a-d).
no-effect levels for samples rich in cracked components (NOAEL = 1-10
mg/kg bw/d) were lower than those where non-cracked material
predominated (NOAEL = 94-2350 mg/kg bw/d) but there were qualitative
similarities in the type of systemic changes observed. Information is
also available from rat sub-chronic dermal toxicity testing of two
straight run samples and eight heavily cracked samples in the rat.
Systemic findings included alterations in haematological parameters
(RBC, HGB, HCT, platelets), clinical chemistry values (cholesterol, BUN)
and organ weights (liver, thymus) with no clear relationship apparent
between refining history and the resultant toxicological responses (i.e.
common and consistent systemic findings were commonly present for both
straight run and cracked samples). The red cell and platelet effects may
have been secondary to bone marrow histopathology reported in rats
following sub-chronic treatment with some Heavy Fuel Oil Components
(e.g. heavy vacuum gas oil, heavy atmospheric gas oil, catalytic cracked
heavy fuel oil, FCCU decant oil).
systemic subchronic dermal NOAEL of 1.06 mg/Kg/day has been reported in
a key study in male and female rats (ARCO, 1993a) while the NOAEL for
local effects has been reported to be 53 mg/Kg/day in female rats in the
same study. In another key but subacute study in rats (ARCO, 1993b), the
systemic NOAEL was reported to be 1 mg/Kg/day in female rats and the
LOAEL for local effects was reported to be 1 mg/Kg/day in both sexes of
rats when the test material was applied undiluted.
there is sufficient evidence to indicate that Heavy Fuel Oil Components
have a potential to cause systemic toxicity following repeated dermal
Justification for selection of repeated dose toxicity dermal -
systemic effects endpoint:
One of 31 available studies
Justification for selection of repeated dose toxicity dermal - local
One of 31 available studies.
Repeated dose toxicity: dermal - systemic effects (target organ)
cardiovascular / hematological: blood coagulation; digestive: liver
There is evidence to indicate that Heavy
Fuel Oil Components have a potential to cause systemic alterations
following repeated dermal exposure. Classification as STOT RE2- H373 is
appropriate under the EU
CLP Regulation (EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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