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EC number: 229-222-8
CAS number: 6440-58-0
Reliable (Klimisch 1) toxicity studies with algae have been conducted for DMDMH and DMH, the hydrolysis product of DMDMH and are included in this dossier. The study Vryenhoef & Mullee (2007) provides an estimated 72hr EC50 of 11 mg/L and 72hr NOEC of 5.1 mg/L, based on growth using DMDMH. Consequently this value will be taken as the toxicity in algae endpoint for DMDMH.
(Klimisch 1 or 2) toxicity studies with algae have been conducted for
DMDMH or the hydrolysis product of DMDMH, DMH and are included in this
dossier. DMDMH readily undergoes hydrolysis to DMH and therefore data
are provided for both substances when available. In the case of
long-term testing, the data on DMH is considered more relevant for
environmental fate and ecotoxicology and are considered in this dossier.
& Mullee (2007) conducted a reliable (Klimisch 1) GLP compliant study
following OECD 201 methods. The algae, Desmodesmus subspicatus, were
exposed to measured concentrations (nominal; 1.0, 3.2, 10, 32 and 100
mg/L) of DMDMH in a static system for 72 hours. The 72hr EC50, EC10 and
NOEC, based on growth, was 11 mg/L, 5.7 mg/L and 5.1 mg/L, respectively.
& Hill (2006) conducted a reliable (Klimisch 1) GLP compliant study
following OECD 201 methods. The algae, Pseudokirchneriella subcapitata,
were exposed to a measured concentration (1000 mg/L) of DMH, the
hydrolysis product of DMDMH in a static system for 96 hours. The 96hr
EC50, based on growth, was >1000 mg/L and the NOEC was 1000 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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