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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Four experiments were conducted as part of the study which involved the determination of the absorption, distribution, metabolism and excretion (ADME) patterns of 14C-5,5-dimethylhydantoin. The dosing regimens were as follows: A single oral low-dose(100mg/kg); a single oral high- dose(;  repeated oral low- dose (100mg/kg/day of non-radiolabelled DMH for days 1-7 and80mg/kg/day for days 8-14 followed by a single dose of 14C-DMH); A single I.V low-dose (100mg/kg)

Key value for chemical safety assessment

Additional information

DMDMH readily undergoes hydrolysis to form DMH. The available data demonstrates that DMH is well absorbed and rapidly and quantitatively excreted, unchanged, in the urine following oral or intravenous administration. There was no evidence for significant tissue accumulation.