Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-222-8
CAS number: 6440-58-0
Four experiments were conducted as part of the study which involved the determination of the absorption, distribution, metabolism and excretion (ADME) patterns of 14C-5,5-dimethylhydantoin. The dosing regimens were as follows: A single oral low-dose(100mg/kg); a single oral high- dose(1000mg.kg); repeated oral low- dose (100mg/kg/day of non-radiolabelled DMH for days 1-7 and80mg/kg/day for days 8-14 followed by a single dose of 14C-DMH); A single I.V low-dose (100mg/kg)
DMDMH readily undergoes hydrolysis to form DMH. The available data
demonstrates that DMH is well absorbed and rapidly and quantitatively
excreted, unchanged, in the urine following oral or intravenous
administration. There was no evidence for significant tissue
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again