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EC number: 235-122-5
CAS number: 12070-10-9
A 0.01% suspension of divanadium
trioxide in aqua ad iniectabilia chosen for the 1st
(intracutaneous) induction stage revealed a discrete or patchy erythema
in all 10 animals 24 hours after administration.
2 mL of a 50% concentration of
divanadium trioxide in aqua ad iniectabilia/animal chosen for the
2nd (topical) induction stage were non-irritating to the shaved skin in
the preliminary experiment. Hence, in the main study the skin was coated
with sodium laurylsulfate on the day before stage 2 induction in order
to induce a local irritation.
The challenge with 2 mL of a 25%
suspension of divanadium trioxide in aqua ad iniectabilia/animal
revealed no skin irritation in any animal and, thus, the test item had
no sensitising properties.
The body weight gain of the animals
treated with divanadium trioxide was within the range of the vehicle
control during the experiment.
Behaviour remained unchanged.
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