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EC number: 235-122-5
CAS number: 12070-10-9
pentoxide as one of 15 other chemical substances was in the in vitro
micronucleus assay in SHE at the following concentrations: 10, 15, 20,
and 25 µg/mL. Dose levels were
selected based on solubility and/or toxicity limits. After a 24-hour
treatment period an aliquot of cells was counted to determine the number
of live cells (determined by trypan blue exclusion) as a measure of
toxicity. Remaining cells were collected by centrifugation, fixed and
stained for analysis. In each treatment group, 500 cells were analysed
to determine the percentage of binucleated cells and 1000 binucleated
cells were analysed to determine the number of micronucleated cells.
Under the test conditions described the test
substance, vanadium pentoxide, has no mutagenic potential in the in
vitro micronuceus test in Syrian hamster embryo (SHE) cells.
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