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EC number: 201-732-5
CAS number: 87-22-9
Table 1.Skin Reaction Scoring System
Barely perceptible erythema
Scattered, mild erythema (faint pink)
Moderate and diffuse erythema (pale pink )
Intense erythema (deep pink) and oedema
Table 2: RESULTS OF PRELIMINARY IRRITATION TEST
A Preliminary irritation tests for
test chemical were performed on male albino Dunkin/Hartley guinea pigs
to determine the concentration for suitable the sensitization study. In
the preliminary test, the guinea pigs were treated intradermally and
dermally. The animals were intradermally injected with 0.1ml aliquots of
a range of concentration of test substance (0.25%,0.5%, 1% or 2%) in 6%
acetone/ 20% PEG 400 /0.01% Tween 80/ saline. During topical
application, animals received a single dermal application of 10%, 25% or
50% test chemical in acetone using 8 mm saturated filter paper and 11 mm
aluminum patch test cups which were applied to the shaved flank for 24
h. Reactions were assessed for irritation at 24 and 48 h after patch
removal. Very slight erythema was observed at 0.25% and 0.5%. Barely
perceptible erythema was observed at 10%, 25% or 50% concentrations.
Since the test chemical induced cutaneous effects at these
concentrations, the test chemical was considered to be slightly
irritating to the skin of albino Dunkin/Hartley guinea pigs. Thus
concentration of 0.5% was selected for the intradermal induction and a
concentration of 50% the test chemical was selected for the topical
induction application. Based on the observations and results, it
was concluded that the test material was considered to be slightly
irritating (Category 2) on male albino Dunkin/Hartley guinea pigs in the
preliminary irritation tests performed for the sensitization study.
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