Phenethyl salicylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from a peer-reviewed publication.

Data source

Reference

Reference Type:

publication

Title:

Acute Oral toxicity study of the test chemical

Author:

A.Lapczynski et al

Year:

2007

Bibliographic source:

Food and Chem. Tox. 2007

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Principles of method if other than guideline:

Equivalent or similar to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

not specified

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Phenethyl salicylate

EC Number:

201-732-5

EC Name:

Phenethyl salicylate

Cas Number:

87-22-9

Molecular formula:

C15H14O3

IUPAC Name:

phenethyl salicylate

Test material form:

solid

Details on test material:

Name: Phenethyl salicylate
Molecular Formula: C15H14O3
Molecular Weight: 242.2726 g/mol
SMILES: c1ccc(cc1)CCOC(=O)c2ccccc2O
Substance Type: Organic
Physical State: Solid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No Data Available

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

single exposure

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

10 rats

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days (or other?) : 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes/no : no
- Clinical signs including body weight : yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:

Statistics:

No Data Available

Results and discussion

Preliminary study:

No Data Available

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

No mortality due to the administration of the test chemical was observed at the given doses. However, one death was observed.

Clinical signs:

other: Slight lethargy was observed at the administered doses.

Gross pathology:

No Data Available

Other findings:

No Data Available

Applicant's summary and conclusion

Interpretation of results:

other: Not Classified

Conclusions:

Slight lethargy was observed during the course of the study. The LD50 exceeded 5 g/kg based on one (1/10) death at that dose. Thus, based on all the observations and results, it was concluded that the test chemical is not acutely toxic to the rats when administered at 5000 mg/kg bw.

Executive summary:

In an acute oral toxicity study, the acute oral LD50 of the test chemical was determined in 10 rats. The rats were observed for mortality and/or systemic effects for 14 days. Slight lethargy was observed during the course of the study. The LD50 exceeded 5 g/kg based on one (1/10) death at that dose. Thus, based on all the observations and results, it was concluded that the test chemical is not acutely toxic to the rats when administered at 5000 mg/kg bw.