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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from a peer-reviewed publication.

Data source

Reference
Reference Type:
publication
Title:
Acute Oral toxicity study of the test chemical
Author:
A.Lapczynski et al
Year:
2007
Bibliographic source:
Food and Chem. Tox. 2007

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Principles of method if other than guideline:
Equivalent or similar to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
not specified
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethyl salicylate
EC Number:
201-732-5
EC Name:
Phenethyl salicylate
Cas Number:
87-22-9
Molecular formula:
C15H14O3
IUPAC Name:
phenethyl salicylate
Test material form:
solid
Details on test material:
Name: Phenethyl salicylate
Molecular Formula: C15H14O3
Molecular Weight: 242.2726 g/mol
SMILES: c1ccc(cc1)CCOC(=O)c2ccccc2O
Substance Type: Organic
Physical State: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No Data Available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
single exposure
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 rats
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days (or other?) : 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes/no : no
- Clinical signs including body weight : yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Statistics:
No Data Available

Results and discussion

Preliminary study:
No Data Available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No mortality due to the administration of the test chemical was observed at the given doses. However, one death was observed.
Clinical signs:
other: Slight lethargy was observed at the administered doses.
Gross pathology:
No Data Available
Other findings:
No Data Available

Applicant's summary and conclusion

Interpretation of results:
other: Not Classified
Conclusions:
Slight lethargy was observed during the course of the study. The LD50 exceeded 5 g/kg based on one (1/10) death at that dose. Thus, based on all the observations and results, it was concluded that the test chemical is not acutely toxic to the rats when administered at 5000 mg/kg bw.
Executive summary:

In an acute oral toxicity study, the acute oral LD50 of the test chemical was determined in 10 rats. The rats were observed for mortality and/or systemic effects for 14 days. Slight lethargy was observed during the course of the study. The LD50 exceeded 5 g/kg based on one (1/10) death at that dose. Thus, based on all the observations and results, it was concluded that the test chemical is not acutely toxic to the rats when administered at 5000 mg/kg bw.