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EC number: 214-881-6
CAS number: 1205-17-0
Table 1: Skin Sensitisation Potential
Concentration (% w/v)
Number of Lymph Nodes Assayed
Disintegrations per Minute (DPM)
DPM per Lymph Node
N/A = Not applicable
HCA = hexylcinnamaldehyde (positive control)
A Local Lymph Node Assay study in the mouse was conducted to investigate
the skin sensitisation potential of the test material in accordance with
the standardised guidelines OECD 429 and US EPA OPPTS 870.2600 under GLP
The test material was applied to the dorsal surface of each ear of
female CBA/Ca mice at concentrations of 2.5, 5, 10, 25 and 50 % w/v in
1:3 Ethanol/Diethylphthalate (1:3 EtOH:DEP). A vehicle control group was
similarly treated using 1:3 EtOH:DEP alone. Four animals were treated in
each dose group. The estimated concentration giving rise to a 3 fold
increase in lymphocyte proliferation (EC3) was calculated as a
percentage dose and µg/cm². A concurrent positive control group was
dosed with hexylcinnamaldehyde at concentrations of 5, 10 and 25 % w/v
in acetone:olive oil (4:1).
The test material had the capacity to cause skin sensitisation when
applied as 25 and 50 % w/v preparations in 1:3 EtOH:DEP. The estimated
EC3 value giving rise to a 3 fold increase in lymphocyte proliferation
was calculated to be 16.4 % w/v (4100 µg/cm²).
In the positive control study, hexylcinnamaldehyde was shown to have the
capacity to cause skin sensitisation when applied as a 25 % w/v
preparation in acetone: olive oil (4:1 ratio), confirming the validity
of the protocol used for this study.
Under the conditions of the study, the test material was considered to
be a skin sensitiser.
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