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EC number: 214-881-6
CAS number: 1205-17-0
The test material was estimated to have a half-life >1 year at pH 4, 7
and 9 at 25 °C.
A study was conducted to investigate the potential hydrolysis as a
function of pH of the test material in accordance with the standardised
guidelines OECD 111 and EU Method C.7 under GLP conditions. The study
was assigned a reliability score of 1 in accordance with the criteria
for assessing data quality set forth by Klimisch et al. (1997).
The potential of the test material to undergo hydrolysis was
investigated at buffer solutions prepared at pH 4, 7 and 9 at 50 °C in
the dark for a period of five days. The buffer solutions were subjected
to ultrasonication and degassing with nitrogen to minimise dissolved
Changes in the concentration of test material were monitored after 24
and 120 h using HPLC analysis with UV detection at 288 nm.
Less than 10 % hydrolysis was seen after 120 hours at 50 °C for all
Under the conditions of this study, the test material was estimated to
have a half-life >1 year at pH 4, 7 and 9 at 25 °C.
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