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EC number: 214-881-6
CAS number: 1205-17-0
Table 1: Body weight, dose volume and dermal reactions
Ear tag # & Sex
Dose volume (cc)
Body Weight (kg) on Day
Skin Reactions on Day
†Body weight verified. This animal died on day 12 with a
terminal body weight of 1.9 kg
E = erythema (redness)
a = dose site stained yellow
f = flaking skin
* = animal re-clipped
% Rem. = a visual estimate of the amount of material
remaining on the skin, gauze and occlusive binding at 24 hours, after
the occlusive binding was removed.
The potential of the test material to cause acute dermal toxicity in the
rabbit was investigated in accordance with the standardised guideline
OECD 402 under GLP conditions.
Five healthy male and five healthy female New Zealand Albino rabbits
were dosed dermally with the test material at 2000 mg/kg of body weight.
The test material was applied to intact skin and covered in an occlusive
fashion for 24 hours. at the end of the exposure period, the test
material was gently washed off with distilled water.
Animals were observed for toxicity and pharmacological effects at 1, 2
and 4 hours post dosing and once daily up to 14 days. Body weights were
recorded pre-test, weekly and at death or termination. The animals were
observed twice daily for mortality. The test sites were scored for
dermal irritation at 24 hours post dose and on days 7 and 14 using the
numerical Draize scale. All animals were examined for gross pathology.
Nine out of ten animals survived the 2000 mg/kg dermal application. One
male rabbit died on day 12 and exhibited pre-death physical signs of
diarrhoea, lethargy and few faeces.
The nine out of ten animals that survived the 2000 mg/kg dermal
application experienced instances of diarrhoea. Dermal reactions, absent
to well defined on day 1 were absent on days 7 and 14. Body weight
changes were normal in all survivors.
Necropsy of the dead animal revealed abnormalities of the treated skin,
lungs, pleural cavity and gastrointestinal tract. The death did not
appear to be related to the treatment with the test material but to a
pulmonary infection. Necropsy results were normal in eight out of the
nine surviving rabbits. One female exhibited liver abnormalities
(nodules on liver).
Under the conditions of this study, the LD50 value was found to be
greater than 2000 mg/kg of body weight.
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