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EC number: 214-881-6 | CAS number: 1205-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
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- Specific investigations
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- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 September 2012 to 12 December 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.934 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Mean concentration from samples 1 and 2
- Details on results:
- The mean concentration was 0.934 g/L at 20.0 ± 0.5 °C (samples 1 and 2), range 0.933 to 0.934 g/L.
On completion of the equilibration period, the samples contained excess, undissolved test material; whereas, after centrifugation, the samples were observed to be free from excess, undissolved test material.
Negligible hydrolysis of the sample solution occurred during the course of the water solubility test (based upon information obtained in the study to determine hydrolysis and data relating to the pH of the test material).
The sample concentration results shown in Table 1 indicate that equilibration was only attained after 48 hours of shaking in the definitive test. Therefore, only the results for Samples 1 and 2 were used in subsequent calculations. Furthermore, the individual results (for Samples 1 and 2) were within ± 15 % of the mean, thus satisfying the acceptability criteria specified in the guidelines.
The linearity of the detector response with respect to concentration was assessed over the concentration range of 11.1 to 221 mg/L. this was satisfactory with a correlation coefficient (r²) of 1.000 being obtained. - Conclusions:
- Interpretation of results: moderately soluble (100 to 1000 mg/L)
Under the conditions of this study, the water solubility of the test material was determined to be 0.934 g/L of solution at 20.0 ± 0.5 °C. - Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions using the flask method.
Following a preliminary test performed in order to select the appropriate method and to determine the approximate amount of test material to be used in the definitive test, three samples of the test material weighing 0.4579, 0.4581 and 0.4533 g were added to three separate flasks and 100 mL aliquots of purified water added to each flask. After preparation, the samples were shaken at approximately 30 °C for 72 hours, 48 hours and 24 hours, respectively. Then, after standing at 20 °C for a period of 24 hours, the contents of the flasks were centrifuged at 13 500 rpm for 15 minutes. The pH of each solution was measured and the concentration of test material in the sample solutions was determined by HPLC.
The sample concentration results indicate that equilibration was only attained after 48 hours of shaking in the definitive test. Therefore, only the results for Samples 1 and 2 were used in subsequent calculations. Furthermore, the individual results (for Samples 1 and 2) were within ± 15 % of the mean, thus satisfying the acceptability criteria specified in the guidelines.
Under the conditions of this study, the water solubility of the test material was determined to be 0.934 g/L of solution at 20.0 ± 0.5 °C.
Reference
Table 1.Concentration (g/L) of test material in the sample solutions
Sample Number |
Time Shaken at ~ 30 ºC (hours) |
Time Equilibrated at 20 ºC (hours) |
Concentration (g/L) |
Solution pH |
1 |
72 |
24 |
0.934 |
4.1 |
2 |
48 |
24 |
0.933 |
3.4 |
3 |
24 |
24 |
0.051 |
4.1 |
Description of key information
The water solubility was determined to be 0.934 g/L of solution at 20.0 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.934 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions using the flask method. The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
Following a preliminary test performed in order to select the appropriate method and to determine the approximate amount of test material to be used in the definitive test, three samples of the test material weighing 0.4579, 0.4581 and 0.4533 g were added to three separate flasks and 100 mL aliquots of purified water added to each flask. After preparation, the samples were shaken at approximately 30 °C for 72 hours, 48 hours and 24 hours, respectively. Then, after standing at 20 °C for a period of 24 hours, the contents of the flasks were centrifuged at 13 500 rpm for 15 minutes. The pH of each solution was measured and the concentration of test material in the sample solutions was determined by HPLC.
The sample concentration results indicate that equilibration was only attained after 48 hours of shaking in the definitive test. Therefore, only the results for Samples 1 and 2 were used in subsequent calculations. Furthermore, the individual results (for Samples 1 and 2) were within ± 15 % of the mean, thus satisfying the acceptability criteria specified in the guidelines.
Under the conditions of this study, the water solubility of the test material was determined to be 0.934 g/L of solution at 20.0 ± 0.5 °C.
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