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EC number: 295-518-9
CAS number: 92062-05-0
A complex combination of hydrocarbons obtained from the vacuum distillation of the products from a thermal cracking process. It consists predominantly of hydrocarbons having carbon numbers predominantly greater than C34 and boiling above approximately 495°C (923°F).
Group mean bodyweight data (+/- SD) n = 21-24
- Test: Dunnett 5% significance level
** - Test:
Dunnett 1% significance level
Table 2 Ceasaren Section Data
Generalised Results - Group Summary by Mixed Parameter / Time
Number of Females Pregnant
Dams with Viable Fetuses
No. Corpora Lutea/Grp
Dunnett 5% significance
Factor Test: Chi-squared p < 0.05
Dunnett 1% significance
The maternal NOAEL was determined to be the low dose group, 50 mg/m³.
Observations at 500 mg/m³ included effects on body weight, food
consumption, lung weight and histopathological changes in the lung and
larynx. At 150 mg/m³ observations were restricted to histopathological
changes in the larynx.
The developmental NOAEL was the medium dose group, 150 mg/m³, due to
reduced fetal weight at 500 mg/m³.
Importantly, nose-only exposure to bitumen fumes in concentrations up to
500 mg/m³ from p.c days 1 to 19, did not induce any fetal anomalies
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