Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-813-5
CAS number: 5989-27-5
Table 1: Body weight and weight gain in
Day 2-Day 0
Day 7-Day 0
Day 14-Day 0
In an oral acute toxicity (limit test) study
performed in accordance with GLP and OECD guideline 423, groups of six
Sprague-Dawley female rats received a single oral (gavage) dose of
dipentene at 2000 mg/kg bw. Animals were then observed for mortality,
body weight and clinical signs of toxicity for 14 days and were all
macroscopically necropsied after sacrifice. The
observations were compared to historical control data.
One animal died on Day 6 during the study. A
decrease in spontaneous activity (4/6), muscle tone and righting reflex
(3/6) and increased salivation and piloerection (3/6) was noted on first
day of study. All animals recovered to normal behavior
at 24 hours post dose. A 7% decrease in body weight on Day 2 was
observed in animal that died on Day 6. In surviving animals absence of
body weight gain was noted on Day 2 that recovered normal body weight on
Day 7. Thickness (5/5) and white coloration (2/5) of forestomach of
surviving animals and white thinning of the corpus of the dead animal
was noted on necropsy. The oral LD50 was found to be greater than 2000
mg/kg bw in rats.
The oral LD50 for dipentene was found to be
greater than 2000 mg/kg bw in the Sprague-Dawley rats and therefore it
is not classified according to Directive 67/548/EEC and CLP Regulation
(EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again