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EC number: 227-813-5
CAS number: 5989-27-5
In an inhalation study, groups of normosmics
(2 females and 1 male) and anosmics (2 females and 2 males) were exposed
to R-(+)-limonene at concentrations of 3.7, 11, 33 and 100%. Stimuli
were presented via 270-mL polypropylene squeeze-bottles containing 30 mL
of solution. Odor and nasal pungency thresholds were measured in
normosmics and anosmics, respectively via a two-alternative
forced-choice procedure with presentation of progressively higher
concentrations. Starting from the lowest concentration, each trial
entailed the presentation of a blank (mineral oil) and a stimulus. The
subject’s task was to choose the stronger stimulus. If the participant
was correct, the same concentration was presented next, paired with a
blank. If the participant was incorrect, the next higher concentration
was presented next, also paired with a blank. The first concentration
chosen correctly five times in a row was taken as the threshold. Each
type of threshold was measured eight times per subject–stimulus
combination. Odor threshold for R-(+)-limonene in normosmics was
determined to be approximately 10 ppm. Nasal pungency was not evoked in
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